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theboywhofangirled:

moriartyandsons:

theboywhofangirled:

idlely-rambling:

sherlocking-my-way-to-gallifrey:

noxbat23:

theboywhofangirled:

LEGS

SHOULDERS

KNEES

AND TOES

YOU IDIOTS IT’S HEAD SHOULDERS KNEES AND TOES GET IT RIGHT

YOU’RE THE ONE THAT STARTED IT WITH LEGS???

THIS WASN’T MEANT TO HAPPEN

(Source: kimpossibooty, via predictablerelapse)

meladoodle:

juilan:

My ears. They are ringing.

are u gonna answer em

(via bagelbrother)

qvw:

reblog if this horse is prettier than you

qvw:

reblog if this horse is prettier than you

(Source: darkfriesiannight, via alittleofthat)

slayer-slayer-slayer:

nico-ahegao:

if you work at a sex shop is it still nsfw

image

(Source: kakerukurosawa, via weedjoke420)

(Source: metaf, via weedjoke420)

I’m in so much pain I could die.

I want this to stop.

internetgirl:

when i was in highschool & begged my mom to see the manson show on a school night & we ended up vip

internetgirl:

when i was in highschool & begged my mom to see the manson show on a school night & we ended up vip

(via violettevenus)

aktx:

tarntino:

me: *sees a white boy* *locks my car doors*

white boy: *knocks on window* what would you be doing if I was in there with you ;)

(via weedjoke420)

Hypersensitivity to Non-Painful Events May Be Part of Pathology in Fibromyalgia

neurosciencestuff:

New research shows that patients with fibromyalgia have hypersensitivity to non-painful events based on images of the patients’ brains, which show reduced activation in primary sensory regions and increased activation in sensory integration areas. Findings published in Arthritis & Rheumatology, a journal of the American College of Rheumatology (ACR), suggest that brain abnormalities in response to non-painful sensory stimulation may cause the increased unpleasantness that patients experience in response to daily visual, auditory and tactile stimulation.

image

Fibromyalgia is a chronic, musculoskeletal syndrome characterized by widespread pain, affecting roughly two percent of the world population, say experts. According to the ACR, five million people in the U.S. have fibromyalgia, which is more prevalent among women. In previous studies fibromyalgia patients report reduced tolerance to normal sensory (auditory, visual, olfactory, and tactile) stimulation in addition to greater sensitivity to pain.

For the present study, researchers used functional magnetic resonance imaging (fMRI) to assess brain response to sensory stimulation in 35 women with fibromyalgia and 25 healthy, age-matched controls. Patients had an average disease duration of 7 years and a mean age of 47.

According to the study, patients reported increased unpleasantness in response to multisensory stimulation in daily life activities. Furthermore, fMRI displayed reduced activation of both the primary and secondary visual and auditory areas of the brain, and increased activation in sensory integration regions. These brain abnormalities mediated the increased unpleasantness to visual, auditory and tactile stimulation that patients reported to experience in daily life.

Lead study author, Dr. Marina López-Solà from the Institute of Cognitive Science, University of Colorado Boulder said, “Our study provides new evidence that fibromyalgia patients display altered central processing in response to multisensory stimulation, which are linked to core fibromyalgia symptoms and may be part of the disease pathology. The finding of reduced cortical activation in the visual and auditory brain areas that were associated with patient pain complaints may offer novel targets for neurostimulation treatments in fibromyalgia patients.”

(Source: eu.wiley.com)

ravclaw:

homework to do: hella

homework i’ve done: negative hella

(Source: tiniestleaf, via thestudyjournal)

I am v emotional right now

favabean05:

staticdiplomat:

pickyourheartupoffthefloor:

the-goddamazon:

lancrebitch:

crunchierkatie:

i love seeing girls close ranks when their fella is cheating, instead of defending him and attacking the other girls. like seriously. it warms my cold, cold heart so much. 

i need the rest of this story, where did you put the body

I’ve always wanted to do this. I hope they all went out for ice cream later too.

i want an update on this

FUCKING AMAZING

FORCED TO FLEE WITH HIS NAN

(Source: twirpy, via nomchimpsky)